Low carb diet, lipids and glucose sensitivity
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I reviewed two latest meta-analyses on low carb diet (LCD) in order to conclude the magnitude of the metabolic outcomes (Hession et al & Kodoma et al.). I synthethized this data with the data from available long term trials (Shai et al 2008, Sacks et al. 2009 and Foster et al 2010). There is no striking deleterious effect of LCD on LDL -level, at most it's modest and compensated by positive changes in HDL, TG and glucose/insulin
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Low carb diet, lipids and glucose sensitivity
- 1. Effects of Low Carb Diet compared to Low Fat diet. Metabolic risk factors. 21/12/14Headline1 Insulinsensitivity and endothelial function?
- 2. Sources • Hession E et al. Systematic review of randomized controlled trials of low- carbohydrate vs. low-fat/low-calorie diets in the management of obesity and its comorbidities. Obesity reviews (2009) 10, 36–50 • Kodoma S et al. Influence of Fat and Carbohydrate Proportions on the Metabolic Profile in Patients With Type 2 Diabetes: A Meta-Analysis. Diabetes Care. 2009 May; 32(5): 959–965. • Foster et al. Weight and Metabolic Outcomes After 2 Years on a Low- Carbohydrate Versus Low-Fat Diet. A Randomized Trial. Ann Intern Med 2010: 153; 147-157 • Sacks et al. Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates. NEJM 2009: 360(9); 859-73 • Shai et al. Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet. NEJM 2008: 359(3); 229-41 21.12.14Headline2